Earlier this year I came into possession of over 50 years worth of housewares, mostly vintage. As much as I would dearly love to keep every single item, I can't, and neither can anyone else. I am thus selling some home decor pieces at my sister Etsy shop, for anyone interested in period accessories. There are also other items, including vintage clothing and jewelry, books and craft magazines.
I think it's a good idea to clear out every few years, to allow new things into you life - not necessarily "things", but ideas, interests, and people. I am a pack rat, probably a life-long one, but I have a good eye and tend to hold on to interesting items rather than junk, but taste can change, and when that happens, it's good to pass along what no longer thrills you to someone else.